Clinical Aspects in Epstein-barr and Cytomegalic Virus Co-infection in Children

Background Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) usually cause primary and latent infections during childhood. Thus, a co-infection with these viruses can also occur occasionally in children. However, its clinical impact has not been yet established, and may be underestimated. Aim – The authors described 5 cases of Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) co-infection in children, emphasizing the polymorphism of clinical manifestations. Methods Case report 1 is a 3 years old child with prolonged fever in the context of a good general condition. Case report 2 is a 18-month-old toddler with hepatocytolisis and mild jaundice. Case report 3 is a 5 years old child with acute tonsilitis and generalized adenomegaly. Case report 4 is a teenager with toxic appearance, prolonged high fevers, chills, fatigue, and malaise, myalgias, headache, and pain in the left upper quadrant, splenomegaly. Case 5 is a teenager with high fever, myalgias, headache, acute tonsilitis, hepatosplenomegaly, exudative pharyngitis and cervical lymphadenopathy, moderately elevated serum levels of aminotransferases. In all cases the serology was positive